We excluded people with evidence of symptomatic cardiovascular

We selected a higher cut off point (0.99 v 0.9) for the trial as it is recognised that calcification in the vessels of people with diabetes can produce normal or high ankle brachial pressure indexes, even in the presence of arterial disease. We excluded people with evidence of symptomatic cardiovascular disease; those who use aspirin or antioxidant therapy on a regular basis; those with peptic ulceration, severe dyspepsia, a bleeding disorder, or intolerance to aspirin; those with suspected serious physical illness (such as cancer), which might have been expected to curtail life expectancy; those with psychiatric illness (reported by their general practitioner); those with congenital heart disease; and those unable to give informed consent.Trial proceduresPotentially eligible participants attending the diabetes clinics during the enrolment period were invited to join the trial. If they agreed they were screened for eligibility.

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